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Publications

Full citations below

Transplantation of committed pre-adipocytes from brown adipose tissue improves whole-body glucose homeostasis

Repurposing Decellularized Lung to Generate Vascularized Fat

Optimization and validation of a fat-on-a-chip model for non-invasive therapeutic drug discovery

Unilocular adipocyte and lipid tracer for immunofluorescent images

Adipose Tissue Development Relies on Coordinated Extracellular Matrix Remodeling, Angiogenesis, and Adipogenesis

Development of a More Environmentally Friendly Silk Fibroin Scaffold for Soft Tissue Applications

Adipose Tissue Paracrine-, Autocrine-, and Matrix-Dependent Signaling during the Development and Progression of Obesity

A Preliminary Study on Factors That Drive Patient Variability in Human Subcutaneous Adipose Tissues

Correlation matrix for adipose tissue factors

Therapeutic Ultrasound Triggered Silk Fibroin Scaffold Degradation

The Materiobiology of Silk: Exploring the Biophysical Influence of Silk Biomaterials on Directing Cellular Behaviors

Silk Fibroin as a Green Material

Engineering a 3D Vascularized Adipose Tissue Construct Using a Decellularized Lung Matrix

Human Adipose Derived Cells in Two- and Three-Dimensional Cultures: Functional Validation of an In Vitro Fat Construct

Mechanisms of action, chemical characteristics, and model systems of obesogens

Adipose Tissue Fibrosis: Mechanisms, Models, and Importance

Work in Progress: Incorporating interactive modules related to cell culture and plasmid design into introduction to biomedical engineering

Depiction of a student doing active learning

Microscopic considerations for optimizing silk biomaterials

Modeling Diabetic Corneal Neuropathy in a 3D In Vitro Cornea System

3D printing with silk: considerations and applications

Fat-on-a-Chip models for research and discovery in obesity and its metabolic co-morbidities

Variability in responses observed in human white adipose tissue models

Development of a Three-Dimensional Adipose Tissue Model for Studying Embryonic Exposures to Obesogenic Chemicals

Image of adipocytes differentiated in BPA

Expandable and Rapidly Differentiating Human Induced Neural Stem Cell Lines for Multiple Tissue Engineering Applications

Cells maintain neuronal and glial phenotypes in long-term cultures

3D biomaterial matrix to support long term, full thickness, immuno-competent human skin equivalents with nervous system components

Histology of three dimensional skin constructs

The Use of Silk as a Scaffold for Mature, Sustainable Unilocular Adipose 3D Tissue Engineered Systems

Image of adipose tissue in a silk scaffold.

Engineering Biomaterials for Enhanced Tissue Regeneration

Engineering strategies to enhance tissue regeneration

Serially Transplanted Nonpericytic CD146(-) Adipose Stromal/Stem Cells in Silk Bioscaffolds Regenerate Adipose Tissue In Vivo

Silk as a Biomaterial to Support Long-Term Three-Dimensional Tissue Cultures

Silk scaffolds can be used for many different tissue types

Non-invasive Assessments of Adipose Tissue Metabolism In Vitro

Strategies for improving the physiological relevance of human engineered tissues

Long term perfusion system supporting adipogenesis

Multifunctional spider silk polymers for gene delivery to human mesenchymal stem cells

3D Tissue Engineered Systems for Regenerative Approaches, Drug Discovery, and Toxicity Screening

Injectable silk foams for soft tissue regeneration

Degenerative grade affects the responses of human nucleus pulposus cells to link-N, CTGF, and TGFβ3

Stress and matrix-responsive cytoskeletal remodeling in fibroblasts

Live free or die: stretch-induced apoptosis occurs when adaptive reorientation of annulus fibrosus cells is restricted

Regenerative potential of TGFβ3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells

Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells

Effects of enzymatic digestion on compressive properties of rat intervertebral discs

Full Citations:

2017- present

Johnston EK, Dassau T, Muraskin NA, Abbott RD. Automated adipocyte and lipid tracer for immunohistochemistry images. Sci Rep. 2025 Feb 7;15(1):4643.

Huff LK, Amurgis CM, Kokai LE, Abbott RD. Optimization and validation of a fat-on-a-chip model for non-invasive therapeutic drug discovery. Front Bioeng Biotechnol. 2024 Jun 25:12:1404327.

Huff LK, Ling Z, DeBari MK, Ren X, Abbott RD. “Repurposing Decellularized Lungs to Generate Vascularized Fat.” Adipose-Derived Stem Cells Methods and Protocols. 3rd edition. Edited by Jeffrey Gimble, Bruce Bunnell, Cecilia Sanchez, and Trivia Frazier. Lab protocol Series - Methods in Molecular Biology, published by Springer Nature 2024.

Dewal RS, Yang FT, Baer LA, Vidal P, Hernandez-Saavedra D, Seculov NP, Ghosh A, Noé F, Togliatti O, Hughes L, DeBari MK, West MD, Soroko R, Sternberg H, Malik NN, Puchulu-Campanella E, Wang H, Yan P, Wolfrum C, Abbott RD, Stanford KI. Transplantation of Committed Pre-adipocytes from Brown Adipose Tissue improves Whole-body Glucose Homeostasis. iScience. 2024 Jan 17.

DeBari MK, Johnston EK, Griffin MD, Scott JV, Ilzuka E, Sun W, Webster-Wood VA, Abbott RD. A Preliminary Study on Factors That Drive Patient Variability in Human Subcutaneous Adipose Tissues. Cells 2024, 13(15), 1240.

Roblin NV, DeBari MK, Shefter SL, Iizuka E, Abbott RD. Development of a More Environmentally Friendly Silk Fibroin Scaffold for Soft Tissue Applications. Journal of Functional Biomaterials. 2023 Apr 18;14(4):230.

Johnston EK, Abbott RD. Adipose Tissue Paracrine-, Autocrine-, and Matrix-Dependent Signaling during the Development and Progression of Obesity. Cells. 2023, 12(3), 407.

Johnston EK, Abbott RD. Adipose Tissue Development Relies on Coordinated Extracellular Matrix Remodeling, Angiogenesis, and Adipogenesis. Biomedicines. 2022, 10(9), 2227.

DeBari MK, Ng WH, Griffin MD, Kokai LE, Marra KG, Rubin JP, Ren X, Abbott RD. Engineering a 3D Vascularized Adipose Tissue Construct using a Decellularized Lung Matrix. Biomimetics. 2021, 6(3), 52.

DeBari MK, King C, Altgold TA, Abbott RD. Silk Fibroin as a Green Material. ACS Biomater Sci Eng. 2021 Jul 14.

Kochhar D, DeBari MK, Abbott RD. The Materiobiology of Silk: Exploring the Biophysical Influence of Silk Biomaterials on Directing Cellular Behaviors. Front Bioeng Biotechnol. 2021;9:697981.

DeBari MK, Niu X, Scott JV, Griffin M, Pereira SR, Cook KE, He B, Abbott RD. Therapeutic Ultrasound Triggered Silk Fibroin Scaffold Degradation. Adv Healthc Mater. 2021 Mar.

Abbott RD, LeBlanc S, Melville MC, Moore S, Zapanta CM. Work in progress: Incorporating interactive modules related to cell culture and plasmid design into introduction to biomedical engineering. American Society of Engineering Education. June 2020.

DeBari MK, Abbott RD. Adipose Tissue Fibrosis: Mechanisms, Models, and Importance. International Journal of Molecular Sciences. 2020 Aug; 21(17).

Griffin MD, Pereira SR, DeBari MK, Abbott RD. Mechanisms of Action, Chemical Characteristics, and Model Systems of Obesogens. BMC Biomed Eng. 2020; 2: 6.

Bender R, McCarthy M, Brown T, Bukowska J, Smith S, Abbott RD, Kaplan DL, Williams C, Wade J, Alarcon A, Wu X, Lau F, Gimble JM, Frazier TP. Human Adipose Derived Cells in Two- and Three-Dimensional Cultures: Functional Validation of an In Vitro Fat Construct. Stem Cells Int. 2020; 2020: 4242130.

McCarthy M, Brown T, Alarcon A, Williams C, Ma M, Wu X, Abbott R, Gimble J, Frazier T. Fat-on-a-Chip models for research and discovery in obesity and its metabolic co-morbidities. Tissue Eng Part B Rev. 2020 Mar 26.

DeBari MK, Keyser MN, Bai MA, Abbott RD. 3D printing with silk: considerations and applications. Connect Tissue Res. 2018 Dec 17:1-11.

Deardorff PM, McKay TB, Wang S, Ghezzi CE, Cairns DM, Abbott RD, Funderburgh JL, Kenyon KR, Kaplan DL. Modeling Diabetic Corneal Neuropathy in a 3D In Vitro Cornea System. Sci Rep. 2018 Nov 23;8(1):17294.

DeBari MK, Abbott RD. Microscopic considerations for optimizing silk biomaterials. WIREs Nanomed Nanobiotech nol. 2018;e1534.

Lightfoot-Vidal SE, Tamamoto KA, Nguyen H, Abbott RD, Cairns DM, Kaplan DL. 3D Biomaterial Matrix to Support Long Term, Full Thickness, Immuno-competent Human Skin Equivalents. Biomaterials. Accepted April 24, 2018.

Abbott RD, Borowsky FE, Alonzo C, Zieba A, Georgakoudi I, Kaplan DL. Variability in responses observed in human white adipose tissue models. J Tissue Eng Regen Med. 2018 Mar;12(3):840-847.

Wang RY*, Abbott RD*, Zieba A, Borowsky FE, Kaplan DL. Development of a Three-Dimensional Adipose Tissue Model for Studying Embryonic Exposures to Obesogenic Chemicals. Ann Biomed Eng. 2017 Jul;45(7):1807-1818.
* These authors contributed equally to this work.

2009-2016

Cairns DM, Chwalek K, Moore YE, Kelley MR, Abbott RD, Moss S, Kaplan DL. Expandable and Rapidly Differentiating Human Induced Neural Stem Cell Lines for Multiple Tissue Engineering Applications. Stem Cell Reports. 2016 Sep 13;7(3):557-570.

Abbott RD, Wang RY, Reagan MR, Borowsky FE, Zieba A, Marra KG, Rubin JP, Ghobrial IM, Kaplan DL. The use of silk as a scaffold for mature, sustainable unilocular adipose 3D tissue engineered systems. Adv Healthc Mater. 2016 Jul;5(13):1667-77.

Abbott RD, Kaplan DL. Engineering Biomaterials for Enhanced Tissue Regeneration. Current Stem Cell Reports. 2016 Jun; 2(2):140-146.

Frazier TP, Bowles A, Lee S, Abbott R, Tucker HA, Kaplan D, Wang M, Strong A, Brown Q, He J, Bunnell BA, Gimble JM. Serially transplanted non-pericytic CD146- Adipose Stromal/Stem Cells in silk bioscaffolds regenerate adipose tissue in vivo. Stem Cells. 2016 Apr;34(4):1097-111.

Abbott RD, Kimmerling EP, Cairns DM, Kaplan DL. Silk as a Biomaterial to Support Long-Term Three-Dimensional Tissue Cultures. ACS Appl Mater Interfaces. 2016 Aug 31;8(34):21861-8.

Abbott RD, Borowsky FE, Quinn KP, Bernstein DL, Georgakoudi I, Kaplan DL. Non-invasive assessments of adipose tissue metabolism in vitro. Ann Biomed Eng. 2016 Mar;44(3):725-32.

Abbott RD, Kaplan DL. Strategies for improving the physiological relevance of human engineered tissues. Trends Biotechnol. 2015 Jul;33(7):401-7.

Abbott RD, Raja WK, Wang RY, Stinson JA, Glettig DL, Burke KA, Kaplan DL. Long term perfusion system supporting adipogenesis. Methods. 2015 Aug;84:84-9.

Tokareva OS, Glettig DL, Abbott RD, Kaplan DL. Multifunctional spider silk polymers for gene delivery to human mesenchymal stem cells. J Biomed Mater Res B Appl Biomater. 2015 Oct;103(7):1390-401.

Abbott RD, Kaplan DL. 3D Tissue Engineered Systems for Regenerative Approaches, Drug Discovery, and Toxicity Screening. JoVE. 2014 Oct 16; 5517.

Bellas E, Lo TJ, Fournier EP, Brown JE, Abbott RD, Gil ES, Marra KG, Rubin JP, Leisk GG, Kaplan DL. Injectable Silk Foams for Soft Tissue Regeneration. Adv Healthc Mater. 2015 Feb 18;4(3):452-9.

Abbott RD, Purmessur D, Monsey RD, Brigstock DR, Laudier DM, Iatridis JC. Degenerative Grade Affects the Responses of Human Nucleus Pulposus Cells to Link-N, CTGF, and TGFβ3. J Spinal Disord Tech. 2013 May;26(3):E86-94.

Abbott RD, Koptiuch C, Iatridis JC, Howe AK, Badger GJ, Langevin HM. Stress and matrix-responsive cytoskeletal remodeling in fibroblasts. J Cell Physiol. 2013 Jan;228(1):50-7. *Highlight article

Abbott RD, Howe AK, Langevin HM, Iatridis JC. Live free or die: Stretch-induced apoptosis occurs when adaptive reorientation of annulus fibrosus cells is restricted. Biochem Biophys Res Commun. 2012 May 4;421(2):361-6.

Abbott RD, Purmessur D, Monsey RD, Iatridis JC. Regenerative Potential of TGFβ3+Dex and Notochordal Cell Conditioned Media on Degenerated Human Intervertebral Disc Cells. J Orthop Res. 2012 Mar;30(3):482-8.

Purmessur D, Schek RM, Abbott RD, Ballif BA, Godburn KE, Iatridis JC. Notochordal tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human MSCs. Arthritis Res Ther. 2011 May 31;13(3):R81.

Barbir A, Michalek AJ, Abbott RD, Iatridis JC. Effects of enzymatic digestion on compressive properties of rat intervertebral discs. J Biomech. 2010 Apr 19;43(6):1067-73.